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We have been using Trend's ScanMail for email/dbs, and ServerProtect/Officescan for the Windows servers running domino for about 7 years. They have been near flawless. The biggest issue we have had is with the current Officescan version - if is loads before the http service starts in domino, officescan takes over port 80, and prevents the http service from starting. There are registry entries that can delay officescan for 30secs or what ever is needed to prevent this.
We have also had a barracude email filter in place for the last 4 years, so the Scanmail utility sees very little action from an A/V side.
Overall, Trend lacks in reporting - great info for the last 24 hours. If you need centralized/trend analysis, there are agents and addons to install to centralize those reports to another product - ControlManager (i think). But those have always added to much complexity for our needs.
Feedback response number WEBB8DWLLZ created by ~Andy Nimhipipuljip on 02/09/2011